Cryo-Electron Microscopy Specialist – EMBL Imaging Centre, Heidelberg, Germany


Location:Heidelberg, Germany
Staff Category:Staff Member
Contract Duration:3 years
Grading:6 or 7, depending on experience and qualifications
Closing Date:15 October 2019
Reference Number:HD01574

We are seeking for a highly motivated and interdisciplinary scientist to join the EMBL Imaging Centre (EMBL IC) team. Due to rapid developments in new imaging technologies, the pace of biological and medical discoveries has increased at an unprecedented speed in the 21st century. For the first time, high-resolution electron and light microscopy technologies enable us to directly visualise the molecular machinery of life under native conditions. Consequently, cutting-edge microscopy is becoming a central technological platform for the life sciences. Currently, few scientists have access to the latest imaging technologies, as the instruments are complex in their development, set-up, maintenance and usage. EMBL is currently constructing the EMBL Imaging Centre to make the latest imaging technologies available as quickly as possible to a broad, international user community of researchers from academia to industry. A broad spectrum of imaging technologies covering the scales from structure determination of single protein complexes to imaging whole organisms will be offered, with a special emphasis on cross modality capabilities (correlative microscopy) and bespoke user project support from sample preparation to image analysis provided by dedicated expert service staff. The successful applicant will be part of the EMBL IC Electron Microscopy Team comprising microscopy engineers, application specialists and image analysists, who work in close collaboration with the Advanced Light Microscopy Team. Both teams have the mission of highest-level user service provision and technology development to continuously improve the services. Electron microscopy technologies will cover all scales from single-particle cryo-electron microscopy and cryo-tomography to (cryo-)CLEM and cellular electron microscopy.

Your role

The successful applicant will support users of the EMBL IC in single-particle cryo-electron microscopy and/or cryo-electron tomography. Tasks include introducing new users to the cryo-electron microscopes, assistance and trouble-shooting in sample preparation for single-particle cryo-EM and cryo-tomography, train users in the use of the electron microscopes and auxiliary equipment, maintaining and servicing the microscope hardware and software at a basic level, interacting with the microscope manufacturer and engineers, data collection and evaluation of data, basic, image processing for single-particle and electron tomography, development of novel acquisition schemes and workflows tailored to the EMBL IC. S/he will also participate in the organisation and teaching of courses on electron microscopy techniques for the EMBL IC user community. The successful candidate should be able to work creatively and independently, be well organised, rigorous, and enjoy working in an international team within a highly collaborative atmosphere. Before opening of the EMBL IC the successful candidate will work on the cryo-EM service platform and on selected pilot projects and microscopy technologies.