ELMI was created in 2001 to establish a unique communication network between European scientists working in the field of light microscopy and the manufacturers of their equipment.
DOCTORAL POSITION AT THE UNIVERSITY CÔTE D’AZUR
4D MORPHOMETRIC STUDY OF CELL AND TISSUE SHAPE CHANGES TO COMPUTATIONALLY UNRAVEL THE PROCESS OF SEA URCHIN EMBRYO GASTRULATION
Computational morphometric analysis has become an essential tool in modern biology to better understand how cell and tissue change shape during embryo development. Therefore, exciting collaborations among computer scientists and biologists have arisen to pierce the mystery of how life take shape. In recent years, new microscopy techniques (e.g., SPIM) have enabled the digital image acquisition of developing embryos with unprecedented 3D spatial and temporal resolution allowing a fine reconstruction of all the morphogenetic processes concurring to shape the embryo [1].
The acquisition of 3D+t high resolved image series results in huge amount of data (also referred to as BIG data sets). Basic image processing approaches fail to provide the necessary tools for multi-dimensional image
analysis. We have developed sophisticated image analysis tools to extract multi-dimensional information from BIG data sets [2]. Our image analysis tools were successfully applied to embryos constituted of tens of cells [3].
Very recently, in a joint collaboration between the Morpheme team and the Rauzi team, this computational tool has been extended to temporal 3D image series of the developing sea urchin embryo constituted by more than
1000 cells. These BIG data sets together with our image analysis tools give access for the first time to detailed morphometric information of shape changes of each single cell (tracked over time in 3D) forming the sea urchin
embryo [4].
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Closing date 17 May 2020