Postdoc Scientist, Max-Delbrueck-Center for Molecular Medicine, Berlin, Germany

A Postdoc position is available in a joined project of the Research Groups of Dr. Armin Rehm (Translational Tumorimmunology) and PD Dr. Uta E. Höpken (Microenvironmental Regulation of Autoimmunity and Cancer).

Our laboratories are interested in the elucidation of tumor-stroma interactions in hematological malignancies. To gain a profound understanding of mechanisms that cause leukemia and lymphoma to be addicted to the local microenvironment, we combine animal models, molecular and cellular biology approaches, microscopic imaging and genomics methodologies (Heinig et al., Cancer Discovery. 2014; Rehm et al., Nature Commun. 2014, Rehm et al, Blood, 2011). To further characterize the tumor-stroma interface and to study the dynamic behaviour of tumor cells in situ, we are planning to apply intravital imaging techniques in murine leukemia models. Moreover, based on the lymphoma-induced transcriptomic alterations of the lymph node vasculature we will explore the tissue remodeling and metabolic activation in the endothelial cell compartment. The Max-Delbrück-Center offers a state-of-the-art imaging core facility with access to multiphoton and confocal microscopes and all other technology platforms.

For additional information see the job offer.