The European Molecular Biology Laboratory (EMBL) is one of the highest ranked scientific research organisations in the world. The Headquarters Laboratory is located in Heidelberg (Germany), with additional sites in Barcelona (Spain), Grenoble (France), Hamburg (Germany), Hinxton (UK) and Rome (Italy).
The Ellenberg group in the Cell Biology & Biophysics Unit is looking for postdoctoral fellows to study the dynamic organisation and structure of large macromolecular complexes, such as the nuclear pore and mitotic chromosomes. We are a multidisciplinary team consisting of biologists, chemists and physicists. The overall goal of our group is to systematically elucidate the mechanisms underlying cell division and nuclear organisation. We are developing a broad range of advanced fluorescence-based imaging technologies to assay the functions of the involved molecular machinery non-invasively, automate imaging to address all its molecular components, and computationally process image data to extract biochemical and biophysical parameters. Our research focuses on three areas: systems biology of mitosis, nuclear structure, and molecular mechanisms of meiosis and early embryonic mitosis.
Dependent on the candidate’s background and interest we envision projects in two research directions:
Correlative live-cell and super-resolution imaging to unravel 3D genome dynamics in interphase and cell division.
Correlative live-cell imaging and cryo-electron microscopy to study nuclear pore assembly at molecular resolution.
The successful applicant will apply and correlate advanced imaging technologies. Work will further include development of labelling strategies, which could include genome-editing, in situ hybridisation, and DNA PAINT technology. The work will comprise technical as well as discovery aspects and will be carried out both independently and with internal and external collaborators.
For additional information please visit the job offer.