Postdoc to develop quantitative live-cell imaging in the field of structural biology, DCEXS-UPF, PRBB, Barcelona, Spain
This position is addressed to scientists holding a PhD who are willing to take their next step in the research of fundamental questions in cell biology by increasing the resolutive power of live-cell imaging. Our lab develops intracellular (protein-based)-nanotools that enhance the precision of live-cell imaging measurements. For example, we can measure distances between fluorophores in the range of 2 nm. In practice, this allows us to do structural biology in living cells and embark on biological questions that could not be answered by other means. We now open a postdoc position to strengthen this line of research and to further enhance the capabilities of quantitative live-cell imaging. Understanding the molecular mechanisms that drive life (and those that lead to death) requires structural characterization of the protein machinery sustaining the biology of the cell. Structural biology methods have been largely centered in in vitro approaches, which provides high-resolution measurements but limited physiological relevance. In our lab, we have recently developed a new live-cell structural biology method based on cell engineering and quantitative live-cell imaging. Our approach allows us to investigate chemical structures in vivo. Thus, we can use light microscopy to reconstruct the architecture of molecular assemblies directly in living cells (Picco et al, 2017, Cell). The successful candidate will complement our research activity with his/her expertise in the fields of optical physics, quantitative live-cell imaging and/or image analysis. We seek for a microscopist in the broad sense of the word, with a PhD in physics, biology, mathematics or equivalent… as long as he/she has a strong background in microscopy, biophysics, optical physics or image analysis.