About the ELMI

ELMI was created in 2001 to establish a unique communication network between European scientists working in the field of light microscopy and the manufacturers of their equipment.

PhD student, SR CLEM, Leiden University Medical Centre, The Netherlands

Dear all,

We have an exciting position open for a PhD student to work on super-resolution light microscopy correlated with cryoEM (super-res cryoCLEM).

The projects: We’ve developed a method to perform super-res cryoCLEM on intact mammalian cells using fluorescent proteins (Tuijtel et al, Sci Rep 2019: https://www.nature.com/articles/s41598-018-37728-8). The position involves designing and building the next-generation of cryo-super resolution light microscope, to improve ease of use and explore novel methods for super-res cryoCLEM. This will be performed in collaboration with the head of the LUMC light microscopy facility, Lennard Voortman. Another aspect is to use super-res cryoCLEM to investigate cellular processes, with a focus on the human immune system. Applications include, but are not limited to, in-situ structural biology of antibody binding and effector complexes, phagocytosis, and the biology of antigen processing by MHC complexes.


We prefer a candidate with a background in microscopy, physics or engineering and a relevant MSc degree is required. Alternatively, you have experience in biology/immunology with an evident desire to explore the fundamentals of super-res cryoCLEM.

The lab: We are at the Leiden University Medical Centre (LUMC), in the Netherlands, which is a well-funded lab in a great place to live and work. We are a highly interdisciplinary group, ranging from bionanotechnology, structural biology, to immunology. We routinely collaborate with chemists, biologists, medics and microscopists.

If you are interested, please apply via this link: https://www.lumc.nl/over-het-lumc/werken-bij/overzicht/PhD-kandidaatGeavanceerdeMicroscopievoorImmunologie?setlanguage=English&setcountry=en

The deadline is 28th Feb. I’m very happy to receive informal questions about the position, project, or living in Leiden.

All the best,