PhD student, SR CLEM, Leiden University Medical Centre, The Netherlands

Dear all,

We have an exciting position open for a PhD student to work on super-resolution light microscopy correlated with cryoEM (super-res cryoCLEM).

The projects: We’ve developed a method to perform super-res cryoCLEM on intact mammalian cells using fluorescent proteins (Tuijtel et al, Sci Rep 2019: https://www.nature.com/articles/s41598-018-37728-8). The position involves designing and building the next-generation of cryo-super resolution light microscope, to improve ease of use and explore novel methods for super-res cryoCLEM. This will be performed in collaboration with the head of the LUMC light microscopy facility, Lennard Voortman. Another aspect is to use super-res cryoCLEM to investigate cellular processes, with a focus on the human immune system. Applications include, but are not limited to, in-situ structural biology of antibody binding and effector complexes, phagocytosis, and the biology of antigen processing by MHC complexes.

Profiles: 

We prefer a candidate with a background in microscopy, physics or engineering and a relevant MSc degree is required. Alternatively, you have experience in biology/immunology with an evident desire to explore the fundamentals of super-res cryoCLEM.

The lab: We are at the Leiden University Medical Centre (LUMC), in the Netherlands, which is a well-funded lab in a great place to live and work. We are a highly interdisciplinary group, ranging from bionanotechnology, structural biology, to immunology. We routinely collaborate with chemists, biologists, medics and microscopists.

If you are interested, please apply via this link: https://www.lumc.nl/over-het-lumc/werken-bij/overzicht/PhD-kandidaatGeavanceerdeMicroscopievoorImmunologie?setlanguage=English&setcountry=en

The deadline is 28th Feb. I’m very happy to receive informal questions about the position, project, or living in Leiden.

All the best,

Thom